In exchange for lighter sentences, just like the anti-hero team in Suicide Squad (2016), a new batch of Belle Reve's meta-humans strike a deal with the cold head of Task Force X, Amanda Waller. This time, her ragtag band of super-powered convicts--Harley Quinn, Bloodsport, Peacemaker, King Shark, Polka-Dot Man, and Ratcatcher 2--venture into the peril-laden South American island nation of Corto Maltese to find the Thinker: the evil scientist in charge of the mysterious Project Starfish. But, as the band joins forces with an old leader of the notorious team, humankind is on the verge of extinction.